Table 2 Univariate and multivariate Cox regression analysis of overall survival in metastatic prostate cancer patients.

From: Low TIM3 expression indicates poor prognosis of metastatic prostate cancer and acts as an independent predictor of castration resistant status

Characteristics

Univariate Cox analysis

Multivariate Cox analysis

HR

95% CI

P value

HR

95% CI

P value

Age at TURP

1.008

0.978–1.040

0.601

0.961

0.929–0.994

0.021

cT stage at TURP

 T2

Ref.

  

Ref.

  

 Otherwise

4.853

2.365–9.960

<0.001

2.981

1.381–6.435

0.005

cN stage at TURP

 N0

Ref.

  

Ref.

  

 Otherwise

2.326

1.199–4.512

0.013

1.215

0.538–2.747

0.639

Gleason Score

1.687

1.240–2.295

0.001

1.416

1.006–1.991

0.046

PSA at TURP

0.998

0.997–1.000

0.081

0.999

0.998–1.000

0.231

mPCa subtype

 mHSPC

Ref.

  

Ref.

  

 mCRPC

6.870

3.872–12.190

<0.001

5.222

2.711–10.058

<0.001

ADT prior to TURP

   

—

—

—

 No

Ref.

     

 Yes

24.518

0.616–975.953

0.089

   

Chemotherapy

 No

Ref.

  

Ref.

  

 Yes

2.506

1.468–4.277

0.001

1.688

0.933–3.055

0.084

Radiotherapy

 No

Ref.

  

Ref.

  

 Yes

0.763

0.181–3.218

0.712

0.157

0.030–0.831

0.029

TIM3 expression

 Positive

Ref.

  

Ref.

  

 Negative

2.865

1.224–6.711

0.015

2.976

1.182–7.519

0.021

Back to article page