Table 5 Meta-analysis results for association of five SNPs in CHRNB3 with ND.
SNP | Minor Allele | Chinese Sample (N = 5,055) | Korean Sample (N = 1,970) | European-American Sample 1 (N = 5,616) | European-American Sample 2 (N = 76,957) | Meta-analysis (N = 89,598) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
β (SE) | p value | β (SE) | p value | β (SE) | p value | β (SE) | p value | Combined p-value | |||
rs10958725 | T | −0.15 (0.08) | 0.0519 | −0.18 (0.07) | 0.0137 | −0.22 (0.05) | 3.55E-05 | −0.29 (0.05) | 8.50E-08 | 8.89E-12 | |
rs10958726 | G | −0.26 (0.08) | 0.0015 | −0.18 (0.07) | 0.0097 | −0.24 (0.05) | 1.39E-05 | −0.30 (0.05) | 1.70E-08 | 1.01E-13 | |
rs4950 | G | −0.26 (0.08) | 0.0014 | −0.18 (0.07) | 0.0104 | −0.24 (0.05) | 1.07E-05 | −0.21 (0.06) | 6.00E-04 | 6.50E-8 | |
rs13280604 | G | −0.26 (0.08) | 0.0012 | −0.18 (0.07) | 0.0109 | −0.23 (0.05) | 1.41E-05 | −0.31 (0.05) | 1.30E-08 | 6.86E-14 | |
rs6474415 | G | −0.23 (0.08) | 0.0044 | −0.18 (0.07) | 0.0113 | −0.23 (0.05) | 1.97E-05 | −0.30 (0.05) | 2.90E-08 | 4.17E-13 | |
