Table 1 Descriptive characteristics of study cohorts.
cohort | TwinsUK | Nottingham controls | Nottingham knee OA | |||
|---|---|---|---|---|---|---|
n | 250 | 52 | 62 | |||
sex F | 100% | 57.9% | 61.1% | |||
age mean (SD) | 67.42 | (8.08) | 67.78 | (7.35) | 67.96 | (8.62) |
BMI kg/m2 mean (SD) | 26.55 | (4.40) | 28.24 | (5.12) | 31.11 | (6.43) |
HPT °C mean (SD) | 46.26 | (2.24) | ||||
HPST °C mean (SD) | 47.46 | (1.84) | ||||
K/L grade 0|1|2|3|4 | NA | 0.81|0.19| 0|0|0 | 0 | 0 | 0.11|0.42|0.47 | |||
WOMAC (0–20) pain score mean (SD) | NA | 2.17 | (3.70) | 6.93 | (4.37) | |
Serum bioactive lipids mean (SD) | ||||||
RvD1(pmol/mL) | 0.042 | (0.089) | NA | NA | ||
RvD2 (pmol/mL) | 2.78 | (3.34) | NA | NA | ||
17-HDHA (pmol/mL) | 162.32 | (277.47) | NA | NA | ||
RvD3 (pmol/mL) | 0.23 | (0.53) | NA | NA | ||
RvD5 (pmol/mL) | 0.39 | (1.39) | NA | NA | ||
RvE1 (pmol/mL) | 0.68 | (2.32) | NA | NA | ||
DHA (mmol/L) | 0.14 | (0.05) | NA | NA | ||
total omega 3 (mmol/L) | 0.43 | (0.13) | NA | NA | ||
AA (pmol/L) | 5531.10 | (1949.4) | NA | NA | ||
LTB4 (pmol/mL) | 79.44 | (212.64) | NA | NA | ||
Plasma bioactive lipids mean (SD) | ||||||
RvD1(pmol/mL) | NA | 0.022 | (0.026) | 0.22 | (0.029) | |
RvD2 (pmol/mL) | NA | 1.24 | (1.90 | 0.74 | (0.86) | |
17-HDHA (pmol/mL) | NA | 26.98 | (18.56 | 25.40 | (19.06) | |
DHA (mmol/L) | NA | 0.13 | (0.02) | 0.13 | (0.02) | |
total omega 3 (mmol/L) | NA | 0.34 | (0.08) | 0.33 | (0.07) | |
AA (pmol/L) | 3012.6 | (1553.6) | 3133.38 | (1335.5) | ||
LTB4 (pmol/mL) | 14.86 | (24.87) | 10.27 | (10.93) | ||
