Table 2 Association between serum resolvins and omega-3 fatty acids and heat pain thresholds (HPT) and heat pain super threshold (HPST) in the TwinsUK cohort. Association is expressed as the regression coefficient (beta) and the corresponding 95% confidence intervals (95% CI). The outcomes tested were HPT and HPST in the log scale, resolvin measures were also log transformed and regressons are adjusted for age, BMI and relatedness.

From: Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans

 

logHPT

log HPST

beta

95% CI

p-value

beta

95% CI

p-value

RvD1

−0.005

(−0.046, 0.036)

0.805

−0.046

(−0.120, 0.028)

0.231

RvD2

0.021

(−0.006, 0.048)

0.133

0.000

(−0.051, 0.051)

0.988

17-HDHA

0.035

(0.008, 0.062)

0.012

0.075

(0.024, 0.126)

0.0046

RvD3

−0.023

(−0.050, 0.004)

0.100

−0.032

(−0.083, 0.019)

0.231

RvD5

−0.017

(−0.046, 0.012)

0.242

−0.033

(−0.086, 0.020)

0.226

RvE1

0.003

(−0.026, 0.032)

0.834

−0.017

(−0.072, 0.038)

0.545

DHA

0.017

(−0.016, 0.050)

0.329

0.030

(0.003, 0.057)

0.031

Total omega3

0.017

(−0.016, 0.050)

0.323

0.028

(0.003, 0.053)

0.036

AA

0.0001

(−0.002, 0.003)

0.921

0.002

(−0.004, 0.007)

0.571

LTB4

0.001

(−0.003, 0.005)

0.558

−0.001

(−0.007, 0.005)

0.752

17-HDHA adj(1)

0.033

0.006

0.060

0.018

0.071

0.016

0.126

0.011

DHA adj(1)

0.014

−0.019

0.047

0.410

0.029

0.002

0.056

0.038

  1. 1Model includes both DHA and 17-HDHA in addition to age, BMI and family relatedness. Nominally significant associations are highlighted in bold.
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