Table 3 Association between plasma resolvins, omega-3 fatty acids and OA pain in the Nottingham cohort. The outcome of all regressions is the log-transformed WOMAC pain score (+1). A higher WOMAC score indicates more main. Regressions were first run only in OA patients adjusting for age, sex, BMI and K/L grade. In selected models both 17-HDHA and DHA or total omega 3 were tested for association together, finally association between 17-HDHA and WOMAC scores was tested in the combined case-control group adjusting for OA status in addition to all other covariates.
compound (log) | beta | 95% CI | p-value | |
|---|---|---|---|---|
RvD1 | 0.022 | −0.033 | 0.078 | 0.430 |
RvD2 | 0.029 | −0.095 | 0.152 | 0.649 |
17-HDHA | −0.406 | −0.690 | −0.123 | 0.005 |
total omega3 | −0.375 | −0.775 | 0.024 | 0.065 |
DHA | −1.316 | −2.532 | −0.100 | 0.034 |
(DHA + 17-HDHA in same model) | ||||
17-HDHA | −0.396 | −0.686 | −0.105 | 0.008 |
DHA | −1.282 | −2.582 | 0.018 | 0.053 |
(omega 3 + 17-HDHA in same model) | ||||
17-HDHA | −0.401 | −0.682 | −0.121 | 0.005 |
Total omega3 | −0.352 | −0.779 | 0.074 | 0.106 |
17-HDHA adj for LTB4 | −0.364 | −0.678 | −0.051 | 0.024 |
17-HDHA adj for AA | −0.460 | −0.779 | −0.141 | 0.005 |
(OA + controls) | ||||
log17-HDHA | −0.123 | −0.234 | −0.012 | 0.029 |
