Figure 3
Oral celecoxib treatment normalized tumor vessels and improved tumor perfusion. (A) The pericyte (green) coverage on tumor vessels (red) in the tumor tissues with or without celecoxib treatment and (B) the corresponding percentage of the tumor vessels covered by pericytes (n = 18). SMA antibody was used to label the pericytes. (C) The tumor perfusion after celecoxib treatment was indicated by lectin labeling (green) and (D) the corresponding percentage of the perfused tumor vessels in all tumor vessels (red) (n = 18). Lectin and CD31 was used to label perfused vessels and tumor vessels (including well perfused and non-perfused vessels), respectively. The oral dose of celecoxib was 200 mg/kg/day for 14 days. The bar indicates 100 μm. **P < 0.001 vs. the control group.
