Table 2 Statistically significant associations between triglyceride and methylation levels in the F5L family study and in the MARTHA study.

From: Blood triglyceride levels are associated with DNA methylation at the serine metabolism gene PHGDH

CpG site

Position (Gene)

F5L family study

MARTHA study

β (95% CI)

P-value

β (95% CI)

P-value

cg06500161

21: 43,656,587 (ABCG1)

0.11 (0.073, 0.15)

1.5 × 10−7

0.11 (0.075, 0.15)

1.92 × 10−8

cg14476101

1: 120,255,992 (PHGDH)

−0.21(−0.29, −0.13)

2.3 × 10−7

−0.082 (−0.16, −6.7 × 10−3)

0.048

  1. Associations were tested using a linear regression model (a variance components model in the F5L family study) where cg14476101 methylation levels expressed as M-value were analysed as the outcome, and triglyceride levels as a predictor. Models were adjusted for sex, age and cell type proportions (RUV components in the F5L family study). Statistical significance was assessed with a FDR in the F5L family study (q-value ≤ 0.05) and with a Holm-Bonferroni correction in the MARTHA study (p_corrected ≤ 0.05). CI, confidence interval.
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