Table 4 Effect of BMI on methylation levels at PHGDH cg14476101 without and with adjustment for triglyceride levels in the F5L family and MARTHA studies.

From: Blood triglyceride levels are associated with DNA methylation at the serine metabolism gene PHGDH

 

F5L family study

MARTHA study

Effect size of BMI without triglyceride levels adjustment

−0.011

−0.0069

95% CI

(−0.014, −2.4 × 10−3)

(−0.015, 1.6 × 10−3)

P-value

0.04

0.11

Effect size of BMI with triglyceride levels adjustment

−3.3 × 10−3

−4.9 × 10−3

95% CI

(−0.010, 4.0 × 10−3)

(−0.015, 4.8 × 10−3)

P-value

0.36

0.33

  1. Associations were tested using a linear regression model (a variance components model in the F5L family study) where cg14476101 methylation levels expressed as M-value were analysed as the outcome, and BMI as a predictor. Models were adjusted for age, sex and cell type proportion, with and without triglyceride levels. CI, confidence interval.
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