Table 5 Effect of triglyceride levels on methylation levels at PHGDH cg14476101 by strata without and with adjustment for BMI in the F5L family and MARTHA studies.

From: Blood triglyceride levels are associated with DNA methylation at the serine metabolism gene PHGDH

 

Direct effect, βBC Coef (se), P-value

Indirect effect, βBT * βTC Coef (se), P-value

Total effect βBC + βBT × βTC Coef (se), P-value

Goodness of fit RMSEA (LI, UI)

F5L Family study

−0.12 (0.11), 0.26

−0.195 (0.05), <0.001

−0.32 (0.106), 0.003

<0.001 (<0.001, 0.092)

MARTHA study

−0.14 (0.12), 0.26

−0.081 (0.05), 0.098

−0.22 (0.112), 0.051

<0.001 (<0.001, 0.063)

  1. Associations were tested using a linear regression model (a variance components model in the F5L family study) where cg14476101 methylation levels expressed as M-value were analysed as the outcome, and triglyceride levels as a predictor. We estimated the effects by triglyceride levels strata (triglyceride levels ≥1.12 mmol/L and triglyceride levels <1.12 mmol/L) using a piecewise linear regression model. Models were adjusted for age, sex and cell type proportion (RUV component in the F5L family study) with and without BMI. CI, confidence interval; N, number of individuals in the stratum.
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