Figure 5 | Scientific Reports

Figure 5

From: Development of a novel immunoassay to detect interactions with the transactivation domain of p53: application to screening of new drugs

Figure 5

Development of an AlphaLISA based MDM4-inhibitor screening assay and the specificity of the assay. (a) Robustness of the MDM4-inhibitor screening assay. AlphaLISA signals of 32 positive controls with optimal amounts of cell extracts containing GST (max. signal) and 32 negative controls with the same amount of cell extracts containing MDM4-GST (min. signal) were plotted. (b) Dose-response curves for a few MDM2 inhibitors.

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