Table 3 Relationship between HOMA indices and cognitive composites and neuroimaging/CSF biomarkers in cognitively normal older adults.

Cognitive Composites
	VEM		ViEM		EF		LANG		Global
	β	Sig	β	Sig	β	Sig	β	Sig	β	Sig
HOMA-IR	−0.65	*0.010*	−0.18	0.527	−0.467	*0.046*	−0.21	0.180	−0.68	*0.007*
HOMA-B	−0.09	0.093	−0.04	0.451	−0.10	*0.044*	−0.02	0.459	−0.11	*0.043*
Neuroimaging/CSF Biomarkers
	NAB		HV		CSF T-tau		CSF P-tau		CSF Aβ42		CSF Aβ42:T-tau		CSF Aβ42:P-tau
	β	Sig	β	Sig	β	Sig	β	Sig	β	Sig	β	Sig	β	Sig
HOMA-IR	0.06	0.691	−0.05	0.542	830.2	*0.008*	95.9	*0.014*	−99.2	0.712	−3.30	0.066	−11.9	0.128
HOMA-B	−0.02	0.490	0.01	0.538	125.3	0.08	155.7	0.08	9.63	0.871	−0.52	0.193	−2.05	0.243

Linear regression analysis covarying for (in all dependent variables) APOE ε4, BMI, %Diabetes, %Diabetes medication, %Hypertension and smoker and (for biomarkers only) sex and age. VEM, Verbal Episodic Memory; ViEM, Visual Episodic Memory; EF, Executive Function; LANG, Language; GLOBAL, Global cognitive composite. HV, Intracranial volume corrected Hippocampal Volume; NAB, Neocortical Amyloid Burden; CSF, Cerebrospinal Fluid.

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