Table 4 Relationship between HOMA indices and cognitive composites and neuroimaging/CSF biomarkers in cognitively normal older adults (FEMALES).

From: Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults

Cognitive Composites

    
 

VEM

ViEM

EF

LANG

Global

β

Sig

β

Sig

β

Sig

β

Sig

β

Sig

HOMA-IR

−0.63

0.046

−0.45

0.220

−0.61

0.042

−0.25

0.218

−0.79

0.014

    

HOMA-B

−0.08

0.222

−0.07

0.367

−0.10

0.134

−0.01

0.800

−0.11

0.111

    

Neuroimaging/CSF Biomarkers

 

NAB

HV

CSF T-tau

CSF P-tau

CSF Aβ42

CSF Aβ42:T-tau

CSF Aβ42:P-tau

β

Sig

β

Sig*

β

Sig

β

Sig

β

Sig

β

Sig

β

Sig

HOMA-IR

0.09

0.570

−0. 16

0.155

687.0

0.023

93.4

0.031

−107.8

0.804

−4.64

0.094

−17.4

0.131

HOMA-B

0.01

0.666

−0.02

0.480

136.4

0.056

19.4

0.055

50.2

0.613

−0.65

0.325

−2.44

0.369

  1. Linear regression analysis covarying for (in all dependent variables) APOE ε4, BMI, %Diabetes, %Diabetes medication, %Hypertension and smoker and (for biomarkers only) age. VEM, Verbal Episodic Memory; ViEM, Visual Episodic Memory; EF, Executive Function; LANG, Language; GLOBAL, Global cognitive composite. HV, Intracranial volume corrected Hippocampal Volume; NAB, Neocortical Amyloid Burden; CSF, Cerebrospinal Fluid.
Back to article page