Table 5 Relationship between HOMA indices and cognitive composites and neuroimaging/CSF biomarkers in cognitively normal older adults (MALES).

From: Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults

Cognitive Composites

    
 

VEM

ViEM

EF

LANG

Global

β

Sig

β

Sig

β

Sig

β

Sig

β

Sig

HOMA-IR

−0.63

0.133

0.15

0.731

−0.28

0.452

−0.13

0.601

−0.48

0.252

    

HOMA-B

−0.16

0.057

0.05

0.579

−0.09

0.223

−0.06

0.241

−0.16

0.060

    

Neuroimaging/CSF Biomarkers

 

NAB

HV

CSF T-tau

CSF P-tau

CSF Aβ42

CSF Aβ42:T-tau

CSF Aβ42:P-tau

β

Sig

β

Sig

β

Sig

β

Sig

β

Sig

β

Sig

β

Sig

HOMA-IR

0.00

0.999

0.15

0.227

857.8

0.280

82.0

0.387

−333.0

0.369

−2.53

0.387

−10.45

0.413

HOMA-B

−0.07

0.191

0.04

0.06

134.7

0.448

13.64

0.515

−79.0

0.328

−0.41

0.530

−1.97

0.540

  1. Linear regression analysis covarying for (in all dependent variables) APOE ε4, BMI, %Diabetes, %Diabetes medication, %Hypertension and smoker and (for biomarkers only) age. VEM, Verbal Episodic Memory; ViEM, Visual Episodic Memory; EF, Executive Function; LANG, Language; GLOBAL, Global cognitive composite. HV, Intracranial volume corrected Hippocampal Volume; NAB, Neocortical Amyloid Burden; CSF, Cerebrospinal Fluid.
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