Figure 1

Spline plots for associations of eGFR (A) and BUN (B) with CHD risk. In each subfigure, black line represents hazard ratio (HR) according to the change of kidney function biomarkers; dotted lines depict the 95% confidence interval (CI) of HR. Covariates included in the analyses were age, gender, examination centers, smoking status, passive smoking, drinking status, Body mass index (BMI), total triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), family history of CHD, physical activity (hours per week), history of diabetes, hypertension, history of diuretics usage and eGFR (only for analysis of BUN).