Table 1 Characteristics of the study participants.

From: Associations of estimated glomerular filtration rate and blood urea nitrogen with incident coronary heart disease: the Dongfeng-Tongji Cohort Study

 

Estimated glomerular filtration rate (eGFR)

P

Blood urea nitrogen (BUN)

P

Group 1 (≥90 ml/min/1.73 m2)

Group 2 (60–90 ml/min/1.73 m2)

Group 3 (15–60 ml/min/1.73 m2)

Tertile 1 (<4.6 mmol/l)

Tertile 2 (4.6–5.7 mmol/l)

Tertile 3 (≥5.7 mmol/l)

Participants, N (%)

5261 (31.0)

9991 (58.8)

1737 (10.2)

 

5316 (33.2)

5322 (33.3)

5355 (33.5)

 

Female, N (%)

3091 (58.8)

5380 (53.9)

926 (53.3)

<0.001

3448 (64.9)

2968 (55.8)

2463 (46.0)

<0.001

Age (years; mean ± SD)

58.5 ± 6.4

63.0 ± 7.4

67.2 ± 7.9

<0.001

60.4 ± 7.6

62.1 ± 7.5

63.5 ± 7.6

<0.001

Education < High School, N (%)

3416 (65.4)

6553 (66.2)

1167 (67.7)

<0.001

3488 (66.2)

3464 (65.6)

3513 (66.1)

0.007

Current smoker, N (%)

1086 (20.6)

1841 (18.4)

288 (16.6)

<0.001

901 (17.0)

990 (18.6)

1132 (21.1)

<0.001

Current drinker, N (%)

1265 (23.9)

2255 (22.6)

332 (19.1)

0.002

1081 (20.3)

1206 (22.7)

1299 (24.3)

<0.001

Passive smoking, N (%)

1034 (19.7)

1860 (18.6)

295 (17.0)

0.039

1023 (19.2)

989 (18.6)

947 (17.7)

0.114

BMI (kg/m2; mean ± SD)

24.0 ± 3.4

24.4 ± 3.3

25.0 ± 3.4

<0.001

24.2 ± 3.4

24.4 ± 3.3

24.5 ± 3.3

0.001

Physical activity (hours/wk; median [IQR])

7.0 (3.5, 10.0)

7.0 (3.5, 10.0)

7.0 (3.5, 10.0)

0.306

7.0 (3.5, 10.0)

7.0 (3.5, 10.5)

7.0 (3.5, 10.5)

0.044

Systolic blood pressure (mmHg; median [IQR])

125 (110, 140)

130 (120, 140)

130 (120–140)

<0.001

130 (115, 140)

130 (120, 140)

130 (120, 140)

0.055

Diastolic blood pressure (mmHg; median [IQR])

80 (70, 80)

80 (70, 80)

80 (70, 85)

0.710

80 (70, 85)

80 (70, 85)

75 (70, 80)

<0.001

Total triglyceride (mmol/l; median [IQR])

1.1 (0.8, 1.6)

1.2 (0.9, 1.7)

1.4 (1.0, 2.0)

<0.001

1.21 (0.9, 1.7)

1.22 (0.9, 1.7)

1.14 (0.8, 1.6)

<0.001

Total cholesterol (mmol/l; mean ± SD)

5.1 ± 0.9

5.2 ± 0.9

5.3 ± 1.0

<0.001

5.1 ± 1.0

5.2 ± 0.9

5.2 ± 0.9

<0.001

HDL (mmol/l; mean ± SD)

1.5 ± 0.4

1.4 ± 0.4

1.4 ± 0.4

<0.001

1.4 ± 0.4

1.4 ± 0.4

1.5 ± 0.4

<0.001

LDL (mmol/l; mean ± SD)

2.9 ± 0.8

3.1 ± 0.8

3.0 ± 0.8

<0.001

3.0 ± 0.8

3.0 ± 0.8

3.0 ± 0.8

0.028

Glucose (mmol/l; median [IQR])

5.6 (5.2, 6.1)

5.6 (5.2, 7.3)

5.7 (5.2, 6.4)

<0.001

5.6 (5.2, 6.1)

5.6 (5.2, 6.2)

5.7 (5.3, 6.3)

<0.001

History of diabetes, N (%)

802 (15.2)

1723 (17.3)

402 (23.1)

<0.001

783 (14.7)

911 (17.1)

1077 (20.1)

<0.001

History of hypertension, N (%)

1256 (23.9)

3228 (32.3)

817 (47.0)

<0.001

1405 (26.4)

1658 (31.2)

1917 (35.8)

<0.001

Family history of CHD, N (%)

273 (5.2)

431 (4.3)

42 (2.4)

<0.001

258 (4.9)

248 (4.7)

185 (3.5)

0.001

Diuretics usage, N (%)

48 (1.0)

134 (1.3)

44 (2.5)

<0.001

54 (1.0)

72 (1.4)

84 (1.6)

0.041

BUN (mmol/l; median [IQR])

4.9 (4.0, 5.7)

5.1 (4.3, 6.1)

5.8 (4.8, 6.9)

<0.001

3.9 (3.5, 4.3)

5.0 (4.8, 5.3)

6.5 (6.0, 7.2)

 

eGFR (ml/min/1.73 m2; median [IQR])

96.7 (93.1, 100.9)

77.0 (69.8, 83.3)

54.1 (49.1, 57.3)

 

84.9 (74.1, 94.5)

82.2 (70.7, 93.4)

77.0 (65.3, 89.4)

<0.001

Incident CHD, N (%)

380 (7.2)

1061 (10.6)

305 (17.6)

<0.001

474 (8.9)

538 (10.1)

636 (11.9)

<0.001

  1. Continuous variables were presented as mean ± standard deviation (SD) or median (Inter Quartile Range).
  2. Categorical variables are presented as N (%).
  3. Differences among groups were tested using analyses of variance or nonparametric tests for continuous variables and chi-square tests for categorical variables.
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