Table 3 HRs (95%CI) of CHD for kidney function biomarkers stratified by relavent characteristics.

From: Associations of estimated glomerular filtration rate and blood urea nitrogen with incident coronary heart disease: the Dongfeng-Tongji Cohort Study

 

Groups of eGFR

P for trend*

P for interaction†

N#

Group 1 (≥90 ml/min/1.73 m2)

Group 2 (60–90 ml/min/1.73 m2)

Group 3 (15–60 ml/min/1.73 m2)

Age

     

0.125

   < = 60 years

6984

1 [Ref]

1.06 (0.86–1.31)

1.82 (1.26–2.62)

0.016

 

   >60 years

10005

1 [Ref]

0.96 (0.82–1.13)

1.15 (0.94–1.40)

0.117

 

Gender

     

0.060

   Male

7592

1 [Ref]

0.96 (0.81–1.16)

1.19 (0.92–1.53)

0.219

 

   Female

9397

1 [Ref]

1.05 (0.88–1.25)

1.29 (1.02–1.64)

0.033

 

Current Smoking

     

0.609

   Yes

3215

1 [Ref]

1.16 (0.90–1.50)

1.53 (1.04–2.24)

0.035

 

   No

13774

1 [Ref]

0.97 (0.84–1.12)

1.17 (0.97–1.42)

0.104

 

Hypertension

     

0.287

   Yes

5301

1 [Ref]

1.04 (0.85–1.27)

1.20 (0.94–1.55)

0.125

 

   No

11688

1 [Ref]

0.98 (0.83–1.15)

1.36 (1.08–1.73)

0.035

 

Diabetes

     

0.593

   Yes

2927

1 [Ref]

0.97 (0.74–1.26)

1.23 (0.88–1.71)

0.181

 

   No

14062

1 [Ref]

1.02 (0.88–1.17)

1.22 (1.00–1.50)

0.063

 

BMI

     

0.194

   <24 kg/m2

7930

1 [Ref]

1.20 (0.99–1.46)

1.58 (1.20–2.08)

0.001

 

   > = 24 kg/m2

8833

1 [Ref]

0.89 (0.76–1.05)

1.07 (0.86–1.33)

0.523

 
 

Tertiles of BUN

P for trend*

P for interaction†

N #

Tertile 1 (<4.6  mmol/l)

Tertile 2 (4.6–5.7  mmol/l)

Tertile 3 (≥5.7  mmol/l)

Age

     

0.730

   < = 60 years

6615

1 [ref]

1.00 (0.79–1.27)

0.95 (0.74–1.23)

0.706

 

   >60 years

9378

1 [ref]

1.16 (1.00–1.35)

1.26 (1.08–1.46)

0.004

 

Gender

     

0.667

   Male

7114

1 [ref]

1.14 (0.94–1.38)

1.21 (1.01–1.46)

0.050

 

   Female

8879

1 [ref]

1.09 (0.92–1.29)

1.15 (0.96–1.38)

0.123

 

Current Smoking

     

0.364

   Yes

3023

1 [ref]

1.14 (0.89–1.52)

1.29 (0.98–1.71)

0.066

 

   No

12970

1 [ref]

1.09 (0.94–1.25)

1.13 (0.98–1.31)

0.103

 

Hypertension

     

0.286

   Yes

4980

1 [ref]

1.24 (1.02–1.51)

1.35 (1.11–1.64)

0.003

 

   No

11013

1 [ref]

1.02 (0.87–1.21)

1.05 (0.89–1.25)

0.555

 

Diabetes

     

0.703

   Yes

2771

1 [ref]

1.20 (0.92–1.56)

1.35 (1.04–1.76)

0.027

 

   No

13222

1 [ref]

1.08 (0.94–1.25)

1.13 (0.97–1.30)

0.122

 

BMI

     

0.579

   <24 kg/m2

7482

1 [ref]

1.09 (0.90–1.32)

1.04 (0.85–1.27)

0.788

 

   > = 24 kg/m2

8296

1 [ref]

1.13 (0.96–1.34)

1.28 (1.08–1.51)

0.004

 

eGFR

     

0.015

   > = 60 ml/min/1.73 m2

14318

1 [ref]

1.08 (0.95–1.24)

1.07 (0.93–1.23)

0.393

 

   <60 ml/min/1.73 m2

1653

1 [ref]

1.49 (0.99–2.25)

1.96 (1.33–2.90)

0.001

 
  1. * P value when we assigned the median value to each quartile and entered this as a continuous variable in the model.
  2. In analysis of eGFR, covariates included age, gender, examination centers, smoking status, passive smoking, drinking status, Body mass index (BMI), total triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), family history of CHD, physical activity (hours per week), history of diabetes, hypertension, and history of diuretics usage; in analysis of BUN, covariates additionally included eGFR.
  3. #Some characteristics have missing values hence not the same total N for each stratification characteristics.
  4. † P value for the interaction term of continuous biomarkers*categorical stratifying variable.
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