Table 2 Multivariate Cox regression analysis of prognostic factors with different lymph node classifications for Siewert type II esophogastric junction adenocarcinoma.

From: Prognostic performance of three lymph node staging schemes for patients with Siewert type II adenocarcinoma of esophagogastric junction

Variable

LNM classification

LNR classification

LODDS classification

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Age

 

<0.001

 

<0.001

 

<0.001

<60

Reference

 

Reference

 

Reference

 

60–70

1.493(1.252–1.781)

<0.001

1.471(1.234–1.754)

<0.001

1.465(1.229–1.746)

<0.001

>70

2.303(1.940–2.735)

<0.001

2.286(1.928–2.710)

<0.001

2.308(1.947–2.736)

<0.001

Marital status

 

0.033

 

0.007

 

0.008

Married

Reference

 

Reference

 

Reference

 

Divorced/Separated

1.354(1.074–1.706)

0.010

1.450(1.150–1.829)

0.002

1.460(1.158–1.841)

0.001

Single

1.276(1.021–1.595)

0.032

1.283(1.026–1.605)

0.029

1.270(1.015–1.589)

0.037

Widowed

1.047(0.837–1.310)

0.687

1.109(0.886–1.388)

0.367

1.125(0.899–1.408)

0.304

Unknown

0.885(0.559–1.404)

0.605

0.869(0.549–1.378)

0.551

0.901(0.568–1.430)

0.659

Tumor size

 

0.374

 

0.117

 

0.182

≤3

Reference

 

Reference

 

Reference

 

≤5

1.124(0.910–1.388)

0.279

1.148(0.929–1.418)

0.201

1.140(0.922–1.410)

0.225

>5

0.998(0.797–1.249)

0.985

0.958(0.764–1.200)

0.708

0.961(0.767–1.205)

0.731

unknown

1.148(0.856–1.538)

0.356

1.148(0.857–1.539)

0.355

1.086(0.812–1.454)

0.578

Grade

 

0.171

 

0.133

 

0.105

well

Reference

 

Reference

 

Reference

 

moderately

1.001(0.685–1.462)

0.998

1.034(0.708–1.511)

0.861

1.029(0.704–1.503)

0.884

poorly

1.147(0.788–1.670)

0.474

1.191(0.819–1.733)

0.36

1.193(0.820–1.736)

0.355

undifferentiated

1.571(0.922–2.677)

0.096

1.649(0.967–2.810)

0.066

1.668(0.979–2.842)

0.060

unknown

1.055(0.585–1.903)

0.858

1.079(0.599–1.946)

0.8

1.069(0.593–1.927)

0.825

T stage

 

<0.001

 

<0.001

 

<0.001

T1

Reference

 

Reference

 

Reference

 

T2

1.289(0.953–1.744)

0.099

1.259(0.931–1.704)

0.135

1.364(1.012–1.837)

0.041

T3

1.656(1.270–2.159)

<0.001

1.628(1.246–2.126)

<0.001

1.799(1.393–2.322)

<0.001

T4

1.926(1.460–2.539)

<0.001

1.853(1.404–2.447)

<0.001

2.004(1.532–2.621)

<0.001

LNM

 

<0.001

    

0

Reference

     

1–2

1.795(1.443–2.233)

<0.001

    

3–6

2.346(1.862–2.957)

<0.001

    

≥7

3.290(2.597–4.167)

<0.001

    

LNR

   

<0.001

  

0

  

Reference

   

≤0.125

  

1.459(1.142–1.863)

0.002

  

≤0.425

  

2.215(1.775–2.763)

<0.001

  

≤1

  

3.933(3.125–4.950)

<0.001

  

LODDS

     

<0.001

≤−2.800

    

Reference

 

≤−1.600

    

1.403(1.126–1.748)

0.003

≤−0.310

    

2.343(1.871–2.934)

<0.001

≤4.270

    

3.984(3.161–5.021)

<0.001

  1. LNM: lymph node metastasis.
  2. LNR: positive lymph node ratio.
  3. LODDS: log odds of positive lymph node.
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