Figure 2
From: Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface
The in vivo anti-tubercular activity of the sulfolane series. (a) Therapeutic efficacy of 4 and 5 against Mtb H37Rv in vivo. C57BL/6 J mice (one mouse per dose) were infected by intratracheal instillation with 105 CFU Mtb H37Rv per mouse. The mice were treated orally once a day from day 1 to day 8 and sacrificed on day 9. (b) 4 and 5 were measured in the blood of the infected mice (oral and sc, subcutaneous). Samples from the mice used in the efficacy experiment were taken and analyzed. Graph shows Mtb H37Rv MIC of the inhibitors as a reference.
