Figure 3
From: Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface
l-Tryptophan rescue of M. bovis BCG inhibition by compounds 1, 2 and 3. (a) The MIC of compound 1 was analyzed in the presence and absence of 0.01% l-tryptophan on solid minimal media by plating 104, 103, 102 101 cells (clockwise from top left). (b) The survival of M. bovis BCG in liquid minimal media with 0×, 1×, 5× and 10× MIC compounds 2 and 3 was analyzed in the presence and absence of 0.01% l-tryptophan. Isoniazid (INH) was used as a control, where l-tryptophan does not rescue the inhibition caused by this cell wall biosynthesis inhibitor.
