Figure 8
From: Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface
Location of resistance-conferring mutations in tryptophan synthase. (a) Ribbon diagram of Mtb tryptophan synthase. Residues appearing in resistance-conferring mutations are shown in spheres (green) as is the PLP co-factor (cyan). The inhibitor-binding site is indicated by spheres in yellow. (b) Close-up view of the cluster of resistance sites. Left and right panels are linked by a 90° rotation about the vertical direction. The β-subunit is shown as a ribbon (orange) with a transparent molecular surface, while parts of the α-subunit backbone (blue) are shown for residues in contact with the β-subunit surface. Resistance sites (green) and the PLP co-factor (cyan) are indicated.
