Figure 4 | Scientific Reports

Figure 4

From: A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies

Figure 4

Regulatory effects of TQ-6 on the Src, Syk, and PLCγ2-PKC activation in platelets. Washed platelets were preincubated with TQ-6 or the solvent control (0.5% DMSO) and subsequently treated with either 1 μg/ml collagen, 0.01 U/ml thrombin, 1 μM U46619 or 150 nM PDBu to induce (A) Src, (B) Syk, (C) PLCγ2, (D) PKC activation (pleckstrin phosphorylation) or (E) platelet aggregation. Profiles in (A,B, E) are representative of four independent experiments. Data are presented as means ± standard errors of the means (n = 4). *p < 0.05 and **p < 0.01, compared with the 0.5% DMSO-treated group; #p < 0.05 and ##p < 0.01, compared with the collagen-treated group.

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