Figure 5
From: The role of the immunoproteasome in interferon-γ-mediated microglial activation
Transcriptome changes in BV-2 cells. BV-2 cells were treated with IFNγ and/or ONX-0914 for 24 h and transcriptome profiling by RNA-seq was performed. (a) Differential expression of 3,482 genes after exposure to IFNγ. (b) Differential expression of 2,670 genes between IFNγ exposed and IFNγ and ONX-0914 exposed cells. (c) Expression signature of 703 differential expressed genes by IFNγ exposure that are reversed with co-administration of ONX-0914. (d) Expression signature of immune response enriched genes with differential expression after IFNγ exposure and reversal by co-administration of ONX-0914. Gene ontologies associated with biological processes are enriched by overlapping gene sets and fold-enrichment (Table 2).
