Figure 1

Enrollment flow diagram. A total of 11,370 participants aged from 10 to 15 years who underwent regular health examinations from 1999 to 2008 at MJ Health Screening Centers were enrolled. Among them, the subjects with only one visit (n = 3,545), missing data of MetS components or γ-GT (n = 512), and a history of alcohol consumption, HTN, type 1 diabetes and those taking medications known to affect MetS components or serum γ-GT levels (n = 241) were excluded. The remaining 7,072 subjects were enrolled as the study cohort. In stage 1, the optimal CoVs of baseline γ-GT to differentiate the subjects with and without MetS were identified by ROC curve. Using these CoVs, the aim of second stage was to validate its predictive role on future MetS, HTN and T2DM.