Table 2 Sites of 2′-O-methylation vulnerable to fibrillarin depletion.

From: Identification of sites of 2′-O-methylation vulnerability in human ribosomal RNAs by systematic mapping

 

HCT116 p53 +/+

HCT116 p53 −/−

snoRNA guide

18S

Gm1447#

Gm1447#

SNORD127

28S

Am1326 (1313)

Am1326 (1313)

SNORD18, SNORD18A, SNORD18B, SNORD18C

Cm1340 (1327)

Cm1340 (1327)#

SNORD104

Gm1522 (1509)

Gm1522 (1509)

SNORD2

Cm1881 (1868)#

Cm1881 (1868)#

SNORD48

Am2401 (2388)

Am2401 (2388)#

SNORD68

Um2415 (2402)#

Um2415 (2402)#

SNORD143, SNORD144

Am2787 (2774)

Am2787 (2774)

SNORD99

Cm2824 (2811)

Cm2824 (2811)#

SNORD95

Cm3701 (3680)

Cm3701 (3680)

SNORD88, SNORD88A, SNORD88B, SNORD88C

Gm3744 (3723)

Gm3744 (3723)#

SNORD87

/

Um3925 (3904)#

SNORD52

Gm4042 (4020)

Gm4042 (4020)#

SNORD102

Gm4618 (4588)#

Gm4618 (4588)#

SNORD91A, SNORD91B

Um4620 (4590)

Um4620 (4590)#

SNORD72

  1. Cut-off: 2-fold reduction after 3 days of depletion, observed with both siRNAs, and after progressive reduction. #Also hypomodified in the indicated cell line (see Table 1). For 28S rRNA: new numbering (old numbering). Putative snoRNA guides for which read counts (intracellular abundances) could be retrieved from the RiboMethSeq dataset (see Fig. 5) are indicated in bold.
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