Table 4 Diagnostic performance of preliminary models to predict malignant IPMN pathology¹.

From: Linc-ing Circulating Long Non-coding RNAs to the Diagnosis and Malignant Prediction of Intraductal Papillary Mucinous Neoplasms of the Pancreas

Model/Variables included	AUC (95% CI)	p value	FDR	Accuracy	SE	SP	PPV	NPV
Gender	0.60 (0.43 ~ 0.78)	0.242	0.252	0.61	0.50	0.71	0.58	0.63
Jaundice	0.61 (0.48 ~ 0.75)	0.087	0.095	0.65	0.29	0.94	0.80	0.62
High risk stigmata (HRS)	0.84 (0.71 ~ 0.97)	0.0002	0.004	0.84	0.86	0.82	0.80	0.88
Worrisome features (WF)	0.53 (0.36 ~ 0.70)	0.690	0.690	0.52	0.71	0.35	0.48	0.60
lncRNA signature	0.76 (0.58 ~ 0.94)	0.012	0.022	0.77	0.79	0.76	0.73	0.81
miRNA signature	0.79 (0.63 ~ 0.96)	0.035	0.043	0.74	0.86	0.65	0.67	0.85
Radiomics signature	0.74 (0.55 ~ 0.93)	0.014	0.023	0.77	0.86	0.71	0.71	0.86
miRNAs + Radiomics	0.89 (0.76 ~ 1.00)	0.002	0.009	0.87	0.79	0.94	0.92	0.84
lncRNAs + Radiomics	0.78 (0.61 ~ 0.95)	0.010	0.021	0.81	1.00	0.65	0.70	1.00
lncRNAs + miRNAs	0.83 (0.67 ~ 0.99)	0.013	0.023	0.81	0.79	0.82	0.79	0.82
lncRNAs + Radiomics + miRNAs	0.90 (0.78 ~ 1.00)	0.004	0.010	0.87	0.71	1.00	1.00	0.81
HRS + WF + lncRNAs	0.91 (0.81 ~ 1.00)	0.001	0.007	0.87	0.86	0.88	0.86	0.88
HRS + WF + Radiomics	0.85 (0.70 ~ 1.00)	0.002	0.009	0.84	0.86	0.82	0.80	0.88
HRS + WF + miRNAs	0.94 (0.87 ~ 1.00)	0.001	0.007	0.87	0.93	0.82	0.81	0.93
HRS + WF + lncRNAs + Radiomics	0.91 (0.81 ~ 1.00)	0.003	0.009	0.87	0.86	0.88	0.86	0.88
HRS + WF + lncRNAs + miRNAs	0.95 (0.89 ~ 1.00)	0.001	0.007	0.87	0.93	0.82	0.81	0.93
HRS + WF + lncRNAs + Radiomics + miRNAs	0.95 (0.89 ~ 1.00)	0.003	0.009	0.87	0.93	0.82	0.81	0.93
HRS + WF + gender + Jaundice + lncRNAs + Radiomics + miRNAs	0.97 (0.91 ~ 1.00)	0.010	0.021	0.90	0.93	0.88	0.87	0.94
WF + lncRNAs	0.76 (0.59 ~ 0.94)	0.041	0.049	0.77	0.71	0.82	0.77	0.78
WF + Radiomics	0.78 (0.60 ~ 0.95)	0.021	0.031	0.81	1.00	0.65	0.70	1.00
WF + miRNAs	0.79 (0.62 ~ 0.96)	0.067	0.076	0.81	0.79	0.82	0.79	0.82
WF + lncRNAs + Radiomics	0.82 (0.66 ~ 0.97)	0.015	0.024	0.77	0.86	0.71	0.71	0.86
WF + lncRNAs + miRNAs	0.84 (0.69 ~ 1.00)	0.029	0.039	0.84	0.86	0.82	0.80	0.88
WF + lncRNAs + Radiomics + miRNAs	0.92 (0.83 ~ 1.00)	0.007	0.018	0.87	0.93	0.82	0.81	0.93
WF + gender + Jaundice + lncRNAs + Radiomics + miRNAs	0.92 (0.82 ~ 1.00)	0.027	0.037	0.87	0.93	0.82	0.81	0.93

¹31 IPMN cases (17 benign; 14 malignant) had data types (clinical data, miRNA, radiomic, lncRNA) included in these analyses. AUC = area underneath the curve; SE = sensitivity; SP = specificity; PPV = positive predictive value; NPV = negative predictive value; High risk stigmata = main pancreatic duct involvement/dilatation ≥10 mm, obstructive jaundice with a cystic lesion in the pancreatic head, or an enhanced solid component/nodule within the cyst; Worrisome features = main pancreatic duct dilation 5–9 mm, cyst size >3 cm, thickened enhanced cyst walls, non-enhanced mural nodules, or acute pancreatitis.

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Table 4 Diagnostic performance of preliminary models to predict malignant IPMN pathology¹.

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