Table 1 Population parameter estimates obtained by fitting the multiscale model (Eq. 1)³⁵ to total viral load kinetic data in the SPARE and SYNERGY trials until the end of treatment. Mean population parameter represents the typical value of a parameter in the studied population. The variability of each parameter is shown in the last column. We assumed a log-normal distribution for all parameters except ε_α and ε_s, which were assumed to follow logit-normal distribution. RSE: relative standard error in percentage. When a parameter was fixed to values found in literature and was not estimated, the RSE could not be provided and this is indicated by “−”.

From: The paradox of highly effective sofosbuvir-based combination therapy despite slow viral decline: can we still rely on viral kinetics?