Figure 2
From: Orchestrated Domain Movement in Catalysis by Cytochrome P450 Reductase
Structural information from SANS data on the different redox states of CPR. (a,b) Pairwise distance distribution functions; (a) samples reduced with dithionite; (b) samples reduced with NADPH. The longer ‘tail’ on the distribution functions for the reduced states as compared to the oxidised state demonstrates a more extended average conformation. (c,d) ab initio envelopes calculated using DAMMIF from the scattering curves of (c) oxidised CPR and (d) CPR reduced to the 2e− level with dithionite; in (c and d) the lower envelopes have been rotated 90° about the horizontal axis.
