Figure 3
From: Orchestrated Domain Movement in Catalysis by Cytochrome P450 Reductase
Analysis of SANS data in terms of multiple states. (a–c) Fits to the scattering curve for CPR reduced to the 2e− level with dithionite using one, two or three states (from a 10,000 conformation pool) respectively. (d,e) Fits to the scattering curve for CPR reduced to the 2e− level with dithionite using a two-state model; the extended state was represented by, (d) the model of Hamdane et al.42 or, (e) the model of Huang et al.37; in both cases the crystal structure was used as a model for the compact state. (f,g) Fits to the scattering curve for CPR reduced to the 2e− level with NADPH using a two-state model; the extended state was represented by (f) the model of Hamdane et al.42 or (g) the model of Huang et al.37; in both cases the crystal structure was used as a model for the compact state. In all cases the goodness-of-fit is indicated by the χ2 value.
