Figure 2

BrdU and Ki67 positive cells within each treatment group. (A) There is a 20-fold increase in %BrdU⁺/insulin⁺ cells in control Cre⁻Ex⁺ mice when treated with exendin-4 as compared to untreated Cre⁻Ex⁻ controls. There is no effect of exendin-4 in Cre⁺Ex⁺ mice. (B) There is a 20-fold increase in %Ki67⁺/insulin⁺ cell numbers in control mice treated with exendin-4 (Cre⁻Ex⁺) as compared to saline control (Cre⁻Ex⁻). Again, there is no effect of exendin-4 in Cre⁺Ex⁺ mice. (C) Representative sections show the large islets in exendin-4 treated control Cre-Ex + mice, with many BrdU⁺ proliferating cells. n = 5. All results were mean ± S.E. *p < 0.05, NS, no significance).