Table 1 Summary of anti-influenza viral activity of hit compounds.

From: Structure-based drug discovery for combating influenza virus by targeting the PA–PB1 interaction

compound

Cell-based screening

PA binding

Plaque inhibition assay IC50 (μM)c

MIC (μM)a

KD (μM)b

PA-37

1.7

74.4 ± 27.0

N.D.d

PA-49

1.7

7.5 ± 2.0

0.47 ± 0.13

PA-58

16.6

13.6 ± 5.5

N.D.

PA-107

16.6

105 ± 24.8

N.D.

  1. aMIC; minimum inhibitory concentration.
  2. bObtained from three independent SPR analyses using recombinant PA.
  3. cIC50; half maximal inhibitory concentration.
  4. dNot determined.
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