Figure 2 | Scientific Reports

Figure 2

From: RETRACTED ARTICLE: Activation of PERK-Nrf2 oncogenic signaling promotes Mdm2-mediated Rb degradation in persistently infected HCV culture

Figure 2

HCV infection activates ER-stress response and induces expression of numerous UPR genes for cell survival in infected PHHs and Huh-7.5 cells. (A) Illustrates the mechanisms for how HCV protein accumulation induces ER-stress and activates three branches of UPR gene expression. (B) Cell lysates prepared from infected PHHs were examined for the expression of ER-stress chaperone, Nrf2 activation; UPR genes (PERK, ATF6 and IRE1) by Western blot analysis. (C) UPR gene expression and Nrf2 activation in Huh-7.5 cells after HCV infection.

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