Table 2 Association between MC4R genotype and postpartum changes in body weight and measures of glucose metabolism1,2.

From: The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis

 

TT (n = 713)

CT (n = 439)

CC (n = 56)

Unadjusted β

Unadjusted P-value

Adjusted β

P-value3

Postpartum weight reduction4, kg/y

−7.0 ± 4.3

−6.8 ± 4.2

−6.5 ± 3.6

0.21

0.31

0.20

0.27

Change of BMI5, kg/m2

1.0 ± 2.3

1.2 ± 2.3

1.3 ± 2.5

0.20

0.08

0.20

0.13

Change of fasting glucose5, nmol/L

0.1 ± 1.0

0.1 ± 1.2

0.1 ± 0.9

0.01

0.82

0.03

0.46

Change of 2-h OGTT glucose5, mmol/L

−2.2 ± 2.3

−2.0 ± 2.6

−1.4 ± 2.9

0.34

<0.01

0.25

0.02

Change of HbA1c5, %

−0.2 ± 0.9

−0.2 ± 1.0

−0.0 ± 1.1

0.06

0.24

0.09

0.03

  1. 1Values are unadjusted mean ± SD.
  2. 2CC, homozygote for risk allele; CT, heterozygote; HbA1c, glycated hemoglobin; MC4R, Melanocortin-4 receptor; OGTT, 2-h 75-g oral glucose tolerance test; TT, wild type.
  3. 3Linear Regression. Models were adjusted for age at postpartum, pre-pregnancy BMI, follow-up years since delivery, level of the corresponding biomarkers during the pregnancy, number of children delivered, and family history of diabetes.
  4. 4Weight change from delivery to postpartum 1–5 y.
  5. 5Change from the time point when women were diagnosed with GDM to postpartum 1–5 y.
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