Figure 2 | Scientific Reports

Figure 2

From: Mechanisms of stem cell based cardiac repair-gap junctional signaling promotes the cardiac lineage specification of mesenchymal stem cells

Figure 2

Therapeutic effect of MSCs and HSCs treatment on cardiac functions. (a) Representative pressure volume (PV)-loop graph used to evaluate cardiac performance. (b,c) Compared to untreated MI (MIC), ejection fraction and end-systolic volume were significantly improved when MSC and HSC populations were applied, both as single injection (MI HSC, MI MSC) and co-administration (MIX), n = 7. (d,e) Likewise, PV-loop analysis showed that stem cell treated hearts demonstrated an improved velocity of pressure rise (max/min), compared to the untreated MIC group, n = 7. Graphs are shown as mean ± SEM. Statistical differences were analyzed using one-way ANOVA, followed by Tukey’s post hoc test (*P < 0.05, **P < 0.01, P < 0.001), vs. MIC.

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