Figure 3 | Scientific Reports

Figure 3

From: Mechanisms of stem cell based cardiac repair-gap junctional signaling promotes the cardiac lineage specification of mesenchymal stem cells

Figure 3

Impact of MSCs and HSCs on MI-induced cardiac remodeling and neovascularization defined for co-transplanted cells and single populations. (a) Stem cell treatment (MSC, HSC, MIX) decreased collagen deposition at the infarction border in comparison to untreated MI (MIC), n = 7. (b) Effect of stem cell transplantation on neovascularization determined within the infarcted area. Infiltration of the infarcted scar with new blood vessels was improved in stem cell treated hearts compared to MIC, n = 7. (c) The capillary density in the border zone was significantly higher following single injection or co-administration of MSCs and HSCs, in contrast to untreated MIC, n = 7. Graphs are shown as mean ± SEM. Statistical differences were analyzed using one-way ANOVA, followed by Tukey’s post hoc test (*P < 0.05, **P < 0.01, P < 0.001), vs. MIC.

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