Figure 1

Schematic representation of magnetic liposome-Im-LAMP assay. (A) The presence of P-gp mediates the formation of a sandwiched immunocomplex between Antibody-tagged DNA-encapsulating liposomes and antibody-tagged magnetic beads; (B) liposomes are lysed with the surfactant to release the encapsulated DNA target; (C) DNA targets initiate LAMP reaction yielding fluorescence signal amplification.