Table 2 Top ten functions and diseases predicted to be altered by Tregs expanded at 33 °C in comparison with cells cultured at 37 °C.

From: Mild hypothermia provides Treg stability

 

Disease/function

p-score

Activation z-score a

1

activation of cells

3.18 × 10−13

−4.643

2

development of mononuclear leukocytes

2.55 × 10−13

−4.077

3

generation of cells

1.54 × 10−13

−4.03

4

activation of leukocytes

9.87 × 10−13

−4.027

5

differentiation of cells

3.56 × 10−16

−3.942

6

migration of cells

3.18 × 10−14

−3.919

7

size of body

1.29 × 10−6

−3.881

8

recruitment of leukocytes

2.3 × 10−11

−3.87

9

development of lymphocytes

9.99 × 10−13

−3.819

10

cell movement

1.79 × 10−15

−3.792

  1. The table shows the top 10 Ingenuity Pathway Analysis (IPA) functions and diseases affected by Tregs expanded at 33 °C based on differentially expressed genes in these cells as compared with Tregs cultured at 37 °C.
  2. aAlgorithm in IPA designed to reduce the chance that random data will produce significant prediction. It identifies functions with the strongest prediction for increase (positive z-score) or decrease (negative z-score). Values of p-score <0.05 and z- score ≤−2 or ≥2 are considered significant.