Figure 3 | Scientific Reports

Figure 3

From: A novel approach for the prediction of species-specific biotransformation of xenobiotic/drug molecules by the human gut microbiota

Figure 3

(a) Complete workflow for the construction of DrugBug. Figure 3 (b) Steps for the analysis of a query molecule through DrugBug web server. DrugBug consists of three different components namely, EC class-specific RF module (RF module 1), EC subclass-specific RF module (RF module 2) and a similarity search module. In the given example, the query molecule is analyzed by these modules to identify the EC number and the corresponding metabolic enzyme which was found in two bacterial genomes (M1 and M2). In each of the predicted bacteria (M1 and M2), two or more proteins (P1 and P2) similar to the EC enzyme were found.

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