Table 1 Percentage population (mean ± standard error) of the low PMF energy states.

From: Emergence of Alternative Structures in Amyloid Beta 1-42 Monomeric Landscape by N-terminal Hexapeptide Amyloid Inhibitors

 

S1

S2

S3

S4

S5

S6

Others

Free Aβ 42

11.6 ± 4.7

6.4 ± 0.7

2.6 ± 1.2

13.3 ± 1.5

5.7 ± 1.2

47.0 ± 3.8

13.4 ± 1.8

+WT

9.3 ± 3.7 (F4, A2)

18.0 ± 2.1 (E3, H6)

2.6 ± 0.6 (A2, E3)

18.3 ± 2.8 (R5, F4)

16.5 ± 2.7 (R5, F4)

21.0 ± 3.7 (F4, H6)

14.3 ± 1.9

+A2V

15.2 ± 2.7 (F4, V2)

12.8 ± 0.7 (V2, E3)

4.4 ± 1.0 (F4, V2)

23.1 ± 1.9 (F4, V2)

11.6 ± 1.2 (V2, D1)

21.9 ± 4.6 (F4, R5)

11.0 ± 1.7

+A2T

22.5 ± 1.8 (H6, T2)

6.9 ± 2.0 (T2, E3)

11.1 ± 2.5 (E3, H6)

20.0 ± 1.4 (R5, F4)

7.3 ± 1.0 (R5, E3)

12.9 ± 2.8 (H6, E3)

19.3 ± 1.1

  1. The regions on the PMF landscape, which individually represents at least 10% of the total population, are given in italics and further considered for detailed investigation. Top two residues from Aβ6 in terms of binding frequency with Aβ42 are listed in parentheses.
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