Figure 4
Degeneration of OSN axons in the lateral LPS-treated OB. (a) The diagram showing the topographical projection of OSN axons to the OB. OSNs in the lateral OE project their axons to the ventrolateral part of the OB. (b,c) Glomeruli in the ventrolateral OB are immunopositive for OCAM. The OCAM signal is weaker in the LPS-treated OB at Day 21 (c; green) compared to saline-treated OB (b; green). All nuclei are stained with DAPI (blue). Scale bars, 100 μm. (d) The normalized intensity of OCAM in the GL decreases significantly with LPS treatment compared to saline treatment. Data were analyzed with Mann-Whitney U-test (*p < 0.05, compared to saline-treated control).
