Table 1 Binding prediction of EBV peptides EBNA1562-570, LMP1125-133, LMP2A426-434 to A*02:01, A*02:03, A*02:06 and A*02:07 haplotypes.

From: TCR–like antibodies mediate complement and antibody-dependent cellular cytotoxicity against Epstein-Barr virus–transformed B lymphoblastoid cells expressing different HLA-A*02 microvariants

Peptide

HLA-A

Predicted affinity (nM)

Rank (%)

Bind Level

EBNA1562-570 FMVFLQTHI

02:01

21.27

0.3

++

02:03

6.93

0.17

++

02:06

28.81

0.6

+

02:07

27279.25

4.5

−

LMP1125-133 YLLEMLWRL

02:01

2.13

0.01

++

02:03

7.58

0.2

++

02:06

2.84

0.01

++

02:07

11737.13

0.6

+

LMP2A426-434 CLGGLLTMV

02:01

75.6

0.9

+

02:03

6.79

0.17

++

02:06

109.64

1.5

+

02:07

7667.90

0.25

++

  1. Prediction was performed by employing the online bioinformatics platform NetMHC (version 4.0) (http://www.cbs.dtu.dk/services/NetMHC-4.0/). Strong binders were indicated by a percentile rank (%rank) of less than 0.5, while weak binders ranged between 0.5 to less than 2. Values above 5 were considered as non-binders.
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