Figure 3
Knockdown of mPGES-2 increases the mortality and promotes renal impairment of mice with LPS-induce AKI. (A) Shown is the survival curve of mice with LPS-induced AKI after mPGES-2 inhibition (n = 15). (B) and (C) Shown are the levels of serum urea nitrogen and creatinine, respectively, two indices of renal function, in mice with LPS-induced AKI after mPGES-2 inhibition (n ≥ 6). (D) Shown are the results of HE staining, indicating kidney injury in mice with LPS-induced AKI after mPGES-2 inhibition (n ≥ 6). Scale bar: 50 μm. (E) Shown are kidney injury scores in mice with LPS-induced AKI after mPGES-2 inhibition (n ≥ 6). (F) Shown are the kidney PGE2 content in mice with LPS-induced AKI after mPGES-2 inhibition. *P < 0.01 versus the NS group. # P < 0.05 versus the LPS + control shRNA group. Data are mean ± SD.
