Table 1 Genes encoding proteins associated with HIV proteins +, upregulated; −, downregulated.
Gene Name | Regulation | Functional Category | Proposed Role in HIV Replication |
|---|---|---|---|
CD2 | + | Cell adhesion molecules | HIV-1 latency |
CD40L | + | TNF superfamily member | Immunological control of viral replication |
TAF9,CDK8,MED21 | + | Facilitate RNAP II complex function | Regulate Tat mediated HIV-1 transactivation; |
AP1S2 | + | mediates the recruitment of clathrin | Interact with HIV-1 gp41 or Nef protein |
AP3M1 | + | Facilitates the budding of vesicles | Viral Budding |
CCR5 | + | Chemokine receptor | Viral entry, Chemokine signaling pathway |
FN1 | + | Bind to integrin | Binds to HIV-1 gp120/160 and increase infection |
LAMC1 | + | extracellular matrix glycoproteins | Upregulated by HIV infection or Tat protein |
MANEA | + | Endomannosidase | Process of HIV-1 gp160 formation |
NUP54 | + | Nuclear pore protein | Nuclear import of PIC |
PLS1 | + | Actin-binding protein | Interact with HIVgp41 |
SDC2 | + | Syndecan proteoglycan | Interact with HIV gp120, Tat and Matrix |
TJP1 | + | Tight junction proteins | gp120-mediated tight junction disruption |
UBE2D1 | + | Ubiquitin enzyme | Ubiquitination of HIV-1 Tat |
FCAR | − | Immunoglobulin | The phenotype and function of monocytes |
MKNK2 | − | Protein kinases (CAMK) | MEK2-ERK pathway |
ARHGEF1 | − | Rho GTPases | Binds to HIV gp41 |
ESR2 | − | Estrogen receptor | HIV gp120-induced cell death |
EEF1D | − | Translation elongation | Enhance the translation of viral protein |
GAA | − | Glucosidase | Processing of HIV-1 gp120 |
NFKBIB | − | NF-kappa-B inhibitor | NF-kappa-B pathway |
