Figure 3

Bubble plots showing over-represented Reactome pathways in each meta-analysis condition. The size of each bubble represents the number of genes contributing to pathway over-representation (ranging from 3–37), and the z-score indicates whether genes from the pathway were primarily up-regulated (positive z-score) or down-regulated (negative z-score). The FDR q-value cut-off of 0.05 is indicated by the ‘threshold’ line. Detailed over-representation results are provided in Supplementary Table S4.