Figure 4

Common gene and pathway findings across meta-analysis conditions. Heat maps show overlap in (a) the genes differentially-expressed in each meta-analysis condition and (b) the pathways over-represented in each meta-analysis condition. The number of genes/pathways implicated in each meta-analysis condition is shown in parenthesis after the condition name. List intersections (i.e., the number of overlapping genes/pathways), Benjamini–Hochberg adjusted p-values, and Jaccard similarity indices are superimposed on the heat map grid. Note that the genes and pathways implicated in myopia and hyperopia conditions at each time-point are more similar than the genes implicated within each growth condition over time. Supplementary Table S5 provides a detailed list of the overlapping gene and pathway findings.