Figure 6

Many differentially-expressed genes from the meta-analysis have previously been associated with ocular pathologies. (a) Heat map showing overlap between the genes differentially-expressed in each meta-analysis condition and the genes associated with POAG, cataract, sub-clinical AMD, AMD, and CNV. The number of genes associated with each meta-analysis condition and ocular pathology is shown in parenthesis after the list name. List intersections (i.e., the number of overlapping genes) and Benjamini–Hochberg adjusted p-values are superimposed on the grid. Statistically significant overlaps are highlighted in red. (b) Chord diagram showing genes that were both differentially-expressed in the meta-analysis and associated with an ocular pathology (i.e., all intersecting genes from Fig. 5a). Rectangles on the left indicate whether a gene was differentially expressed in early or late myopia or hyperopia conditions. Left-right connections indicate gene associations with ocular pathologies. Over-represented Reactome pathways for the list of meta-analysis/pathology gene commonalities are shown on the bottom right. Symbols preceding gene names in the chord diagram indicate gene contributions to these pathway over-representations.