Figure 6 | Scientific Reports

Figure 6

From: (S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats

Figure 6The alternative text for this image may have been generated using AI.

(S)-Oxiracetam increased the content of anti-oxidants and maintained the homeostasis of Na+ and K+ in the 2-VO rats. In situ MALDI MSI of (a) glutathione, ascorbic acid and taurine, and (b) Na+ and K+ . The brains were rapidly removed, immediately frozen by immersion in N-hexane (−80 °C) and stored at −80 °C until use. Coronal brain sections were cut at a thickness of 10 µm. 1,5-Diaminonaphthalene (1,5-DAN) hydrochloride was used as the matrix in this experiment. Mass imaging data were acquired in negative ionization mode at a 200 μm spatial resolution. So: (S)-oxiracetam 200 mg/kg; Rso: oxiracetam 400 mg/kg. Scale bar = 5 mm n = 3 per group.

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