Table 1 Pathway analysis of genes altered by EPC.

Rank	Gene	WT (H/NH)	KO (H/NH)	WT (H/NH)	KO (H/NH)
Rank	Gene	log_FC	log_FC	p value*	p value*
Proteoglycans and associated proteins of the extracellular matrix
2	Prg4	−3.716	4.123	4.80E-07	0.015
4	Itih2	−2.155	1.831	0.0025	0.015
10	Cdh1	−3.417	2.892	8.20E-06	0.13
18	Fmod	−2.94	2.102	0.00022	0.34
21	Ogn	−2.968	2.175	0.00026	0.31
29	Serpind1	−1.967	1.821	0.00091	0.13
40	Thbd	−1.529	1.044	0.0022	0.82
42	Islr	−1.522	1.17	0.0022	1
55	Adamtsl3	−1.441	0.883	0.0056	1
67	Lrg1	−1.912	2.755	0.012	0.31
78	Thbs2	−0.8	0.295	0.02	1
Membrane transporters
11	Slc17a7	1.493	−0.887	1.80E-05	1
14	Slc47a1	−2.767	2.241	0.00011	1
15	Slc22a6	−3.243	2.36	0.00021	0.55
19	Slc26a7	−2.441	1.524	0.00025	1
20	Kcnj13	−3.946	1.636	0.00026	1
22	Slc13a4	−3.013	2.292	4.00E-04	0.13
45	Slc6a12	−3.243	2.764	0.0027	0.47
50	Slc6a13	−2.237	1.858	0.0038	0.12
71	Slc6a20a	−1.624	1.206	0.017	1
83	Slc22a2	−3	2.428	0.029	0.47
Retinoic acid signalling
12	Osr1	−3.284	2.999	3.00E-05	0.13
27	Aldh1a2	−2.505	2.288	7.00E-04	0.13
32	Apod	−0.531	0.387	0.0015	1
41	Cyp26b1	−1.631	0.714	0.0022	1
56	Crabp2	−2.319	2.587	0.0064	0.13
64	Rbp1	−1.025	0.906	0.01	1
Wnt signalling
10	Cdh1	−3.417	2.892	8.20E-06	0.13
24	Wnt6	−2.471	1.873	0.00044	0.55
53	Itgbl1	−2.073	1.833	0.0048	0.49
63	Trabd2b	−1.453	0.973	0.01	1
68	Shisa3	−1.401	0.407	0.013	1
82	Emilin1	−1.335	0.636	0.025	1
85	Plac8	−3.255	0.508	0.029	1

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