Figure 2
From: Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease
Cell proliferation is significantly reduced in the hippocampus of APP/PS1 mice at 6 months of age. (A) Light microscopic images of double immunolabeled cells, BrdU (blue)-DCX (brown), in the DG of 2- and 6-months-old WT (a1 and a2), and APP/PS1 (a3 and a4) mice. (B) The total number of BrdU/DCX-positive cells was significantly reduced in APP/PS1 mice compared to WT mice at 6 months of age (n = 4/age/genotype); ANOVA F(3,11) = 15.57; Tukey’s post hoc test *p < 0.05, ***p < 0.001. Scale bars: 100 μm (a1–a4).
