Table 4 Varying decreases in serum RPR and TPPA titers in predicting normalization of CSF abnormalities at 6 months after neurosyphilis treatment.

From: Serological Response Predicts Normalization of Cerebrospinal Fluid Abnormalities at Six Months after Treatment in HIV-Negative Neurosyphilis Patients

 

Response of CSF RPR test n/Na (%)

Normalization of CSF leukocyte count n/Nb (%)

Normalization of CSF protein concentration n/Nc (%)

Decrease in serum RPR titer

Null (14 patients)

3/12 (25.0)

7/9 (77.8)

2/8 (25.0)

2-fold (14 patients)

5/11 (45.5)

7/9 (77.8)

1/5 (20.0)

4-fold (19 patients)

11/15 (73.3)

15/17 (88.2)

10/15 (66.7)

8-fold (4 patients)

4/4 (100.0)

4/4 (100.0)

2/2 (100.0)

16-fold (4 patients)

3/3 (100.0)

2/2 (100.0)

3/3 (100.0)

Decrease in serum TPPA titer

Null (33 patients)

12/28 (42.9)

20/24 (83.3)

10/19 (52.6)

2-fold (14 patients)

9/11 (81.8)

9/10 (90.0)

4/9 (44.4)

4-fold (8 patients)

5/6 (83.3)

6/7 (85.7)

4/5 (80.0)

  1. Abbreviations: RPR, rapid plasma reagin; CSF, cerebrospinal fluid.
  2. a45 patients with reactive baseline CSF RPR were included.
  3. b41 patients with an abnormal baseline CSF leukocyte count (>10 cells/μL) were included.
  4. c33 patients with an abnormal baseline CSF protein concentration (>500 mg/L) were included.
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