Figure 5 | Scientific Reports

Figure 5

From: Production of Monoclonal Antibodies to Pathologic β-sheet Oligomeric Conformers in Neurodegenerative Diseases

Figure 5The alternative text for this image may have been generated using AI.

Immunohistochemistry of plasma from p13Bri immunized M4 mouse and five partially purified anti ß-sheet secondary structure conformational monoclonal antibodies on human AD and control brains. (a) Immunolabelling of human AD brain cortex. (b) Human control brain cortex without pathology. Left panel, reactivity of the plasma from p13Bri immunized M4 mouse (green label), green arrows show cytoplasmic staining that extends to processes. Next five panels ammonium sulfate semi-purified anti ß-sheet secondary structure conformational monoclonals. 23B labels cytoplasm, processes and extracellular material; 3D labels the whole neuronal body; 12E shows preference for glial cells; 10E and 10F show similar lighter staining pattern of neuronal cytoplasm, processes and nucleus. Scale bars represent 50 µm.

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